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Holmes is an advocate of numerous charities and causes including Dogs Trust, Variety GB and Northern Ireland Kidney Patients' Association.
Holmes presented the BBC National Lottery game show Jet Set between 20.
The programme returned for a second series in September 2016 and a third in June 2017. Holmes has also appeared on celebrity editions of game shows including Fifteen to One, Call My Bluff, All Star Mr & Mrs, Tipping Point: Lucky Stars, Catchphrase and The Chase.
In 2013, Holmes was a judge on the CBBC Blue Peter talent search for a new presenter, Blue Peter – You Decide. Holmes has also made regular appearances on Big Brother's Bit on the Side He has been a panellist on numerous episodes of Through the Keyhole and appeared in ITV's Guess the Star in 2017.
Holmes has presented coverage of snooker, horse racing and darts on television.
In 1993, Holmes started working at GMTV, hosting the first show on 1 January 1993 with Anne Davies.
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