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British General Edward Braddock was dispatched with Major George Washington as his aide to take Fort Duquesne.
One of its earliest industries was boat building for settlers of the Ohio Country.
The French built Fort Duquesne based on La Salle's 1669 claims.
The French and Indian War, the North American front of the Seven Years' War, began with the future Pittsburgh as its center.
By 1797, glass manufacture began, while the population grew to around 1,400.
Settlers came via routes over the Appalachian Mountains or through the Great Lakes.
Today, Google, Apple Inc., Bosch, Facebook, Uber, Nokia, Autodesk, and IBM are among 1,600 technology firms generating .7 billion in annual Pittsburgh payrolls.